A Guide To Gene Drives

In 2012, Jennifer Dounda and her colleague Emmanuelle Charpentier published an article showing how a specific gene drive, known as CRISPR-Cas9, can be used to “drive” certain genetic properties through wild populations with astonishing ease. Gene drives are natural genetic systems that allow certain genes to bypass the rules of inheritance and thereby make themselves more likely to be passed along. The CRISPR system, modeled after a bacterial immune system, can be used to target and cut out specific sections of DNA (genes) and replace it with another desired sequence. While gene drives have been known about for a long time, the CRISPR system is a landmark discovery because for the first time geneticists have a tool that allows them to easily manipulate the genetic composition of wild populations.

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