Researchers use CRISPR to detect HPV and Zika

Science published three studies today that all demonstrate new uses for CRISPR. The gene editing technology is typically thought of for its potential use in treating diseases like HIVALS and Huntington’s disease, but researchers are showing that applications of CRISPR don’t stop there.

The first study comes from the lab of CRISPR pioneer Jennifer Doudna. Her team discovered that a CRISPR system different from the CRISPR-Cas9 one we’re used to hearing about can not only snip away specific bits of double-stranded DNA, but can then also cut single-stranded DNA that’s near it. After they uncovered this ability of CRISPR-Cas12a, they used it to detect two common types of HPV. Once their CRISPR-Cas12a system detected HPV DNA in infected cells, it cleaved a another piece of DNA that then released a fluorescent signal, providing a visual sign of the presence of HPV. The researchers dubbed the system DETECTR and The Verge reports that it takes around an hour to work and costs less than a dollar.

Read the full article

%d bloggers like this: