The Genetic Rescue Foundation Blog

CRISPR toolbox expanded by protein that cuts RNA in two distinct ways

UC Berkeley biochemist Jennifer Doudna, molecular biologist Robert Tijan and a team of researchers have expanded the role of the newly discovered CRISPR protein C2c2 that targets RNA instead of DNA. C2c2 has been described as an RNA-guided… Read More

A Guide To Gene Drives

In 2012, Jennifer Dounda and her colleague Emmanuelle Charpentier published an article showing how a specific gene drive, known as CRISPR-Cas9, can be used to “drive” certain genetic properties through wild populations with astonishing ease. Gene drives are… Read More

We can now alter the genomes of invasive species to slow their advance. Should we?

It’s a familiar story on islands all over the world where rodents — prolific feeders and breeders — are a leading cause of extinctions. Massive efforts have been undertaken to kill invasive rodents and usually involve broadcasting rodenticide;… Read More

Blogging cells tell their stories using CRISPR gene editing

What would our cells say if they could blog? We’ll soon know – the CRISPR gene editing technique has been adapted to make cells keep a log of what happens to them, written inside their own DNA. Such… Read More

Are the disruptions of uberisation a bane or boon for science?

Uberisation is the latest buzzword to describe the disruption of industries by slick digital platforms connecting workers with specific tasks or services. So where does science stand in the brave new uberised world? For every characteristic of uberisation,… Read More

The Changing Frontier of Science

Cutting-edge science is being conducted at a growing rate outside of traditional institutions- at startups founded by entrepreneurs and funded by venture capitalists, and by a growing base of global citizen scientists networked to each other and equipped… Read More

Tweaking Genes to Save Species

On islands around the globe, invasive rodents are obliterating native plants and animals — many of which exist nowhere else. By some estimates, 90 percent of these archipelagos are plagued by nonnative rodents. Eradicating them could restore ecosystems… Read More

The Augmented Human Being

I worry about a lot of things. I encourage people to worry about a lot of things, but worry in the sense of taking action, doing something about it and being cautious as you do something about it—doing… Read More

Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing

We employed an RNA-guided CRISPR/Cas9 DNA editing system to precisely remove the entire HIV-1 genome spanning between 5′ and 3′ LTRs of integrated HIV-1 proviral DNA copies from latently infected human CD4+ T-cells. Comprehensive assessment of whole-genome sequencing… Read More

In Newly Created Life-Form, a Major Mystery

Peel away the layers of a house — the plastered walls, the slate roof, the hardwood floors — and you’re left with a frame, the skeletal form that makes up the core of any structure. Can we do… Read More

CRISPR: gene editing is just the beginning

Much of the conversation about CRISPR–Cas9 has revolved around its potential for treating disease or editing the genes of human embryos, but researchers say that the real revolution right now is in the lab. What CRISPR offers, and… Read More

An Ecomodernist Manifesto

A good Anthropocene demands that humans use their growing social, economic, and technological powers to make life better for people, stabilize the climate, and protect the natural world. Read the full article